What is GHK-Cu? Research Guide
By UK Peptide Lab Research Team•7 May 2026•7 min read
What is GHK-Cu?
GHK-Cu is a naturally occurring copper tripeptide consisting of glycine, histidine, and lysine bound to a copper(II) ion. First isolated from human plasma by Loren Pickart in 1973, it has since been identified in saliva, urine, and various tissue types. UK researchers can source GHK-Cu 100mg from UK Peptide Lab at 99.95% HPLC-UV/MS purity with full third-party documentation.
Molecular Properties
GHK-Cu has the molecular formula C₁₄H₂₄CuN₆O₄ and a molecular weight of 403.9 g/mol. The copper(II) ion is integral to its biological activity, serving as a cofactor for lysyl oxidase and other metalloenzymes involved in collagen crosslinking and antioxidant defence. The compound is supplied as lyophilised powder with a characteristic blue tint due to the copper complex.
Gene Expression Modulation
Genomic research indicates that GHK-Cu influences the expression of over 4,000 human genes, approximately 6% of the human genome, including genes involved in DNA repair, proteasome function, oxidative stress response, anti-inflammatory pathways, and tissue remodelling. This broad genomic activity makes GHK-Cu a research tool of significant interest in studies of gene regulation and ageing biology.
Research Applications
GHK-Cu is studied in dermatological research models examining collagen synthesis, extracellular matrix remodelling, and skin barrier function; in hair follicle biology; in wound healing models; and in genomic research examining gene expression modulation. The copper ion serves as a cofactor for several metalloenzymes that contribute to its biological activity in research contexts.
Laboratory Handling and Storage
Store lyophilised vials at -20°C in a light-protected environment. Reconstitute with bacteriostatic water by injecting slowly down the inner wall and gently swirling, never shake. The reconstituted blue-tinged solution should be stored at 2-8°C in a light-protected container and used within 4 weeks. GHK-Cu is light sensitive, protect from prolonged UV and fluorescent light exposure throughout handling.
Sourcing GHK-Cu in the UK
UK Peptide Lab supplies research-grade GHK-Cu 100mg at 99.95% HPLC-UV/MS purity, batch UKPL-529, tested by Krause Analytical, with same-day UK dispatch on orders before 2pm GMT and free Royal Mail Tracked shipping over £45. For in-vitro laboratory research only, not for human consumption.
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Disclaimer: This article is for research and educational purposes only. All information provided is not intended as medical advice. UK Peptide Lab products are not for human consumption and are sold strictly for laboratory research use only.