Nootropic Peptides
Adamax
5mg
Extended acetylated Semax analogue. Nootropic and neuropeptide research.
99.2% purity · Third-party tested · Batch UKPL-472 · View certificate
- Same-day dispatch before 3pm, Mon to Fri
- Add £29.01 more for free UK delivery
- Cold-chain shipping. Always. Dry-cold pack, Royal Mail Tracked 24
- Lost, damaged or wrong? Replaced free if you tell us within 48 hours.
- Research use only. For in-vitro laboratory research. Not for use in humans or animals, or in food, drugs or diagnostics. Not evaluated by the MHRA or FDA. The buyer is responsible for handling and regulatory compliance.
Bulk Pricing
Counted across your basket, any mix of products.
| Vials in basket | Discount | Per vial |
|---|---|---|
| 1 | None | £39.99 |
| 3-4 | 5% | £37.99 |
| 5-9 | 8% | £36.79 |
| 10-50 | 12% | £35.19 |
Bacteriostatic Water 10ml
Required to reconstitute lyophilised peptides.
What is Adamax?
Adamax is a synthetic nine-residue analogue of Semax, sequence Ac-Met-Glu-His-Phe-Pro-Gly-Pro-Ala-Gly. It adds an N-terminal acetyl group and a C-terminal Ala-Gly to the Semax heptapeptide. Each Adamax 5mg vial holds white lyophilised powder.
Full description
Semax itself is Met-Glu-His-Phe-Pro-Gly-Pro: the ACTH(4-7) fragment of adrenocorticotropin extended by Pro-Gly-Pro. N-terminal acetylation is a standard way to slow aminopeptidase cleavage, and the Ala-Gly tail makes Adamax a distinct molecule.
Adamax has no published peer-reviewed pharmacology of its own. There are no binding studies, cell studies, animal studies or toxicology data on it in the indexed literature. Every mechanistic statement below comes from the parent Semax literature and is labelled as such.
Adamax Research Applications
There are no published research applications specific to Adamax. Its use is in analogue-versus-parent designs with Semax as the reference arm. Examples are proteolytic stability assays in serum or tissue homogenate, side-by-side BDNF and trkB endpoint assays in neuronal culture, and analytical characterisation of the analogue itself.
Adamax vs Semax
Semax is the characterised compound. Dolotov and colleagues (J Neurochem, 2006) found specific, reversible, calcium-dependent Semax binding sites in rat basal forebrain membranes, with BDNF protein rising in that region. In rat hippocampus, the same group (Brain Res, 2006) reported a 1.4-fold rise in BDNF protein and more trkB activation after a single application. Adamax is the uncharacterised analogue. Whether acetylation makes it more stable than Semax, or whether the parent's BDNF findings carry over, has not been tested. Researchers who need an evidenced compound should choose Semax.
Research Overview
Adamax is often sold simply as a Semax analogue. The most important fact about it is what the literature lacks: no peer-reviewed pharmacology on Adamax itself. Anything said about its mechanism is inference from Semax.
The Semax evidence is specific. In rat basal forebrain membranes, Dolotov and colleagues (J Neurochem, 2006) measured Semax binding with a dissociation constant of about 2.4 nM. BDNF protein rose in that region but not in the cerebellum. In rat hippocampus (Brain Res, 2006) they reported a 1.4-fold rise in BDNF protein, a 1.6-fold rise in trkB phosphorylation, and higher BDNF and trkB mRNA. These are rodent findings about Semax.
Three open questions follow for the analogue. Does N-acetylation change proteolytic stability? Does the C-terminal Ala-Gly change receptor binding or membrane behaviour? Do the BDNF findings reproduce? None has been answered in print. Adamax is not a licensed medicine in the United Kingdom or anywhere else.
Product Specifications
- Molecular Weight
- 1032.2 g/mol
- Sequence
- Ac-Met-Glu-His-Phe-Pro-Gly-Pro-Ala-Gly (N-acetylated nonapeptide on the Semax scaffold)
- Purity
- 99.2% (RP-HPLC)
- Batch
- UKPL-472
- Storage
- -20°C lyophilised, 2-8°C reconstituted
- Appearance
- White lyophilised powder
- Form
- Lyophilised powder
- CAS Number
- Not assigned
- Molecular Formula
- C50H69N11O11S
Certificate of Analysis
Third-party tested
- Batch
- UKPL-472
- Purity
- 99.2%
- Specification
- ≥98.0%
- Method
- RP-HPLC
- Tested
- Jul 2026
Need the certificate for an earlier batch? Request an older CoA
Storage and Reconstitution
Keep sealed vials at -20°C, away from light and moisture. After reconstitution, keep the solution at 2-8°C and use it within 4 weeks, or freeze single-use aliquots at -20°C. Methionine oxidation is the likeliest degradation route, so protect solutions from light and air.
Vials are sold on their own, without bacteriostatic water for mixing or other supplies.
How to reconstitute and handle
Bring the vial to room temperature and swab both stoppers with alcohol. Add bacteriostatic water slowly down the inside wall of the vial and swirl gently until dissolved. Do not shake or vortex. The solution should be clear and colourless. The methionine at position 1 oxidises easily, so limit air and light exposure and keep the vial capped. Label it with the reconstitution date.
- Work aseptically with sterile syringes and alcohol-swabbed stoppers. Split reconstituted stock into single-use aliquots, label each with the date, and avoid repeated freeze-thaw cycles.
For the full method, see the peptide reconstitution guide and the reconstitution calculator.
Research References
- Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus (2006) (parent compound Semax literature)
- Semax binds specifically and increases levels of brain-derived neurotrophic factor protein in rat basal forebrain (2006) (parent compound Semax literature)
Published research on Adamax is indexed on PubMed.
Adamax Price (UK)
Adamax 5mg is for sale at £39.99 per vial, supplied from stock in the UK with a published third-party HPLC certificate. UK delivery is £4.50 by Royal Mail Tracked 24, free over £69.
| Vial | Price | Cost per mg | Availability |
|---|---|---|---|
| Adamax 5mgThis page | £39.99 | £8.00 | Low stock |
Prices are in GBP per vial and match the basket. See the FAQ for delivery and payment options, and quality & testing for how each batch is checked.
Frequently Asked Questions
Is Adamax the same as Semax?
No. Semax is the heptapeptide Met-Glu-His-Phe-Pro-Gly-Pro. Adamax adds an N-terminal acetyl group and a C-terminal Ala-Gly, giving a nine-residue peptide. That makes it a distinct molecule. Semax has a preclinical literature on receptor binding and BDNF in rat brain, and Adamax has none, so findings for one cannot be assumed for the other.
Are there any published studies on Adamax itself?
Essentially none. No peer-reviewed binding studies, cell work, animal pharmacology or toxicology on Adamax appear in the indexed literature. The only relevant published science is on the parent compound, Semax. Confident mechanistic claims about Adamax elsewhere are extrapolation, not evidence.
What does the parent Semax literature actually show?
Two 2006 rat studies from Dolotov and colleagues are the core. Semax bound specifically to basal forebrain membranes and raised BDNF protein there. In the hippocampus it raised BDNF protein 1.4-fold and increased trkB activation and mRNA. These are findings about Semax in rodents. Whether Adamax behaves the same way is untested.
Why does Adamax have no CAS number?
It has never been registered, which reflects how little formal characterisation it has had. Several numbers circulate between suppliers, and one of them belongs to Semax. Identity rests on the sequence and the batch certificate, which for batch UKPL-472 reports 99.2% purity by RP-HPLC.
Is Adamax legal to buy in the UK?
Yes, as a research chemical for in-vitro laboratory use only. Adamax is not a licensed medicine in the UK and is not supplied for human consumption, veterinary use or any therapeutic purpose. Buyers must be 18 or over and confirm research-only use at checkout.
Where can I buy Adamax in the UK?
UK Peptide Lab sells Adamax 5mg from UK stock, batch UKPL-472. Orders placed before 3pm UK time on a working day are dispatched the same day. UK Royal Mail Tracked delivery is free over £69.
Is your Adamax independently tested?
Yes. Batch UKPL-472 has a third-party certificate reporting 99.2% purity by RP-HPLC, published in full on the product page. With no CAS number and no literature of its own, that batch certificate is the main identity document for the material.
What is Adamax used for in research?
Adamax has no published studies of its own, so there are no established research applications. It suits analogue-versus-parent designs against Semax, such as comparative stability assays or BDNF and trkB endpoint assays in neuronal culture.
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