Nootropic Peptides
Epithalon
10mg
Tetrapeptide bioregulator (Ala-Glu-Asp-Gly). Telomere and circadian research.
98.5% purity · Supplier-reported analysis · Batch UKPL-9501 · View certificate
- Same-day dispatch before 3pm, Mon to Fri
- Add £51.01 more for free UK delivery
- Cold-chain shipping. Always. Dry-cold pack, Royal Mail Tracked 24
- Lost, damaged or wrong? Replaced free if you tell us within 48 hours.
- Research use only. For in-vitro laboratory research. Not for use in humans or animals, or in food, drugs or diagnostics. Not evaluated by the MHRA or FDA. The buyer is responsible for handling and regulatory compliance.
Bulk Pricing
Counted across your basket, any mix of products.
| Vials in basket | Discount | Per vial |
|---|---|---|
| 1 | None | £17.99 |
| 3-4 | 5% | £17.09 |
| 5-9 | 8% | £16.55 |
| 10-50 | 12% | £15.83 |
Bacteriostatic Water 10ml
Required to reconstitute lyophilised peptides.
What is Epithalon?
Epithalon is a synthetic tetrapeptide, Ala-Glu-Asp-Gly, from research into peptide bioregulators. Studies have examined its reported effects on telomerase activity and telomere length, and on melatonin and cortisol rhythms in animal models.
Full description
It is also written Epitalon or Epithalone, and abbreviated AEDG. Its formula is C₁₄H₂₂N₄O₉, its molecular weight 390.35 g/mol and its CAS number 307297-39-8. Vladimir Khavinson's group at the St Petersburg Institute of Bioregulation and Gerontology designed it from Epithalamin, a polypeptide extract of bovine pineal gland studied since the early 1980s.
The group proposes that very short peptides act directly on gene expression, and that four residues are small enough to enter cells unaided. That is a hypothesis of the programme, not an established mechanism. Each Epithalon 10mg vial holds white lyophilised powder.
Epithalon Research Applications
- Telomerase: in telomerase-negative human fetal fibroblasts, Khavinson, Bondarev and Butyugov (Bull Exp Biol Med, 2003) reported expression of the telomerase catalytic subunit, telomerase activity and telomere elongation.
- Independent replication: a 2025 Brunel University London study reported telomere lengthening in normal human fibroblasts and epithelial cells through telomerase, after 3 weeks of culture. The alternative lengthening pathway (ALT) was switched on only in breast cancer lines (Al-Dulaimi et al., Biogerontology, 2025).
- Lifespan in mice: in female SHR mice, mean lifespan did not change (Anisimov et al., Biogerontology, 2003). The last 10% of survivors lived 13.3% longer, and maximum lifespan rose 12.3%.
- Tumour models: the same group reported fewer tumours per rat, 2.7 against 4.1, in dimethylhydrazine-induced colon carcinogenesis (Cancer Lett, 2002).
Study details
Typical in-vitro work measures telomerase activity and telomere length in cultured human cells. Animal work covers lifespan, survival curves, ageing biomarkers and tumour incidence in rodents. Most primary data come from one research cluster, much of it published in Russian, and independent replication is only beginning. Epithalon is not a licensed medicine in the UK, the EU or the United States.
Epithalon vs Pinealon
Both are short synthetic bioregulator peptides from the same St Petersburg programme. Epithalon is the tetrapeptide Ala-Glu-Asp-Gly, designed from the pineal extract Epithalamin, and its literature centres on telomerase and ageing in mice. Pinealon is the tripeptide Glu-Asp-Arg, and its literature leans towards neuroprotection and antioxidant endpoints. Both literatures come mostly from one research cluster, with little outside replication. They are not interchangeable. A design built on the telomere work needs Epithalon; one built on the neuroprotection work needs Pinealon.
Research Overview
Companion work to the 2003 study reported more proliferation of retinal and pigmented epithelial cells in culture. In the 2025 Brunel study, normal cells needed about 3 weeks of exposure, while the telomerase-positive cancer lines responded within 4 days.
The mouse lifespan study also reported 17.1% fewer chromosome aberrations in bone marrow cells, and no change in total spontaneous tumour incidence (Anisimov et al., 2003). The evidence base is mostly Russian-language, uses small samples and has sparse independent replication. Epithalon is not an approved medicine.
Product Specifications
- Molecular Formula
- C₁₄H₂₂N₄O₉
- Molecular Weight
- 390.35 g/mol
- CAS Number
- 307297-39-8
- Sequence
- Ala-Glu-Asp-Gly (AEDG)
- Purity
- 98.5% (HPLC, supplier-reported)
- Batch
- UKPL-9501
- Storage
- -20°C lyophilised, 2-8°C reconstituted
- Appearance
- White lyophilised powder
- Form
- Lyophilised powder
Certificate of Analysis
Supplier-reported analysis. Independent third-party verification pending.
- Batch
- UKPL-9501
- Purity
- 98.5%
- Specification
- ≥98.0%
- Method
- RP-HPLC
- Tested
- Sep 2026
Need the certificate for an earlier batch? Request an older CoA
Storage and Reconstitution
Move vials to the freezer on arrival and keep them dark and dry. The sequence has no labile residues, so sterility sets the in-use limit more than chemistry. Split reconstituted stock into single-use aliquots instead of puncturing one vial again and again.
Vials are sold on their own, without bacteriostatic water for mixing or other supplies.
How to reconstitute and handle
Let the vial reach room temperature. Wipe the stoppers of the peptide vial and the bacteriostatic water vial with an alcohol swab. Add the water slowly down the inside wall of the vial, not onto the powder. Swirl gently until dissolved, and do not shake or vortex. The tetrapeptide has no methionine, cysteine or tryptophan and dissolves readily to a clear, colourless solution. Keep the stopper open briefly and label the vial with the date.
- Work aseptically with sterile syringes and alcohol-swabbed stoppers, and re-seal promptly.
- Aliquot reconstituted stock into single-use volumes and avoid repeated freeze-thaw.
For the full method, see the peptide reconstitution guide and the reconstitution calculator.
Research References
- Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells (Khavinson et al., Bull Exp Biol Med, 2003)
- Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice (Anisimov et al., Biogerontology, 2003)
Published research on Epithalon is indexed on PubMed.
Epithalon Price (UK)
Epithalon 10mg is for sale at £17.99 per vial, supplied from stock in the UK with a published supplier batch certificate. UK delivery is £4.50 by Royal Mail Tracked 24, free over £69.
| Vial | Price | Cost per mg | Availability |
|---|---|---|---|
| Epithalon 10mgThis page | £17.99 | £1.80 | In stock |
Prices are in GBP per vial and match the basket. See the FAQ for delivery and payment options, and quality & testing for how each batch is checked.
Frequently Asked Questions
What does the research show about Epithalon and telomeres?
Two in-vitro studies report telomere lengthening. Khavinson, Bondarev and Butyugov (Bull Exp Biol Med, 2003) found telomerase expression, activity and telomere elongation in human fetal fibroblasts. An independent 2025 study from Brunel University London found telomerase-driven lengthening in normal cells, with ALT activity only in cancer lines (Al-Dulaimi et al., Biogerontology, 2025). The literature is still small.
What is the connection between Epithalon and the pineal gland?
Epithalon was designed from Epithalamin, a polypeptide extract of bovine pineal gland. Much of the melatonin literature uses that parent extract. In healthy elderly subjects, Korkushko and colleagues (Bull Exp Biol Med, 2004) reported that Epithalamin raised night-time melatonin in people with low pineal function at baseline. In those with normal function, melatonin tended to fall.
Is your Epithalon supplier-tested, with independent verification in progress?
Yes. The supplier's analysis of batch UKPL-9501 reports 98.5% purity by RP-HPLC and 9.88mg measured content against the 10mg label. Independent third-party testing is pending. The certificate is published with this listing, and its batch number matches the one printed on the vial.
Where can I buy Epithalon in the UK?
UK Peptide Lab sells Epithalon 10mg vials from UK stock. Orders placed before 3pm on a working day are dispatched the same day by Royal Mail Tracked, and UK delivery is free over £69. It is sold for in-vitro research only, to buyers aged 18 or over.
What is Epithalon used for in research?
Telomere and ageing research. In-vitro models measure telomerase activity and telomere length, following Khavinson, Bondarev and Butyugov (Bull Exp Biol Med, 2003). Animal models look at lifespan, ageing biomarkers and carcinogenesis, following Anisimov and colleagues (Biogerontology, 2003; Cancer Lett, 2002).
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