Nootropic Peptides
DSIP
10mg
Nonapeptide sleep and stress research, 10mg vial.
98.80% purity · Supplier-reported analysis · Batch UKPL-9513 · View certificate
- Same-day dispatch before 3pm, Mon to Fri
- Add £41.01 more for free UK delivery
- Cold-chain shipping. Always. Dry-cold pack, Royal Mail Tracked 24
- Lost, damaged or wrong? Replaced free if you tell us within 48 hours.
- Research use only. For in-vitro laboratory research. Not for use in humans or animals, or in food, drugs or diagnostics. Not evaluated by the MHRA or FDA. The buyer is responsible for handling and regulatory compliance.
Bulk Pricing
Counted across your basket, any mix of products.
| Vials in basket | Discount | Per vial |
|---|---|---|
| 1 | None | £27.99 |
| 3-4 | 5% | £26.59 |
| 5-9 | 8% | £25.75 |
| 10-50 | 12% | £24.63 |
Bacteriostatic Water 10ml
Required to reconstitute lyophilised peptides.
What is DSIP?
Delta sleep-inducing peptide (DSIP) is a nonapeptide (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) first isolated from rabbit cerebral venous blood. Research has examined its reported effects on sleep architecture, stress hormone regulation and circadian rhythms, with human evidence remaining limited. This 10mg presentation is the higher-mass research format of our 5mg vial.
Full description
DSIP 10mg holds the same delta sleep-inducing peptide as our 5mg vial, at twice the mass. It is a nonapeptide, Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu, with a free acid C-terminus, a molecular weight of 848.8 g/mol and CAS number 62568-57-4. Its international nonproprietary name is emideltide. Schoenenberger and Monnier isolated it from rabbit cerebral venous blood (Proc Natl Acad Sci U S A, 1977). They named it for the delta-wave EEG activity its intraventricular infusion appeared to produce in recipient animals.
Much of its biology is still open. No receptor has been identified, no gene encoding it has been isolated, and whether it occurs naturally is disputed. Kovalzon and Strekalova (J Neurochem, 2006) called it a still unresolved riddle.
DSIP Research Applications
- Sleep: in a 1977 double-blind test in 58 rabbits, only synthetic DSIP of nine related peptides gave specific EEG enhancement.
- Replication: Kovalzon and Strekalova (J Neurochem, 2006) call the sleep-factor case poorly documented, noting that some DSIP analogues, not DSIP itself, promoted slow-wave sleep.
- Stress axis: in vitro, DSIP inhibited corticotropin-releasing factor-induced ACTH release from rat anterior pituitary tissue (Okajima and Hertting, Horm Metab Res, 1986). The effect peaked at 10 nM, and basal ACTH did not change.
- Circadian rhythm: Graf and Kastin (Neurosci Biobehav Rev, 1984) catalogued effects on circadian and locomotor patterns and on circulating hormone levels.
Study details
The primary literature is old, uneven and in places contradictory. DSIP is best treated as a compound for hypothesis testing and replication, not a tool with a known mechanism.
DSIP 10mg vs DSIP 5mg: Choosing the Research Format
Both vials hold the identical compound, with the same sequence, CAS number and lyophilised form. The difference is logistics. The 5mg vial suits pilot work and single assays. The 10mg vial puts twice the mass in one container, so a long series needs fewer vials and fewer reconstitutions, and vial-to-vial variation matters less. That headroom suits replication work, which the uneven DSIP literature needs.
Research Overview
DSIP is an unusually acidic nine-residue peptide, formula C₃₅H₄₈N₁₀O₁₅. The Basel group recovered it from rabbits during electrically induced slow-wave sleep. The material enhanced delta and spindle EEG activity after intraventricular infusion in recipient rabbits (Schoenenberger and Monnier, 1977).
Human evidence is limited. Early studies reported effects on disturbed sleep (Schneider-Helmert and Schoenenberger, Neuropsychobiology, 1983). A later double-blind matched-pairs study in 16 chronic insomniac patients found weak, partly confounded effects (Bes et al., Neuropsychobiology, 1992). DSIP is not an approved medicine in the UK, the EU or the United States.
Product Specifications
- Molecular Formula
- C₃₅H₄₈N₁₀O₁₅
- Molecular Weight
- 848.8 g/mol
- CAS Number
- 62568-57-4
- Sequence
- Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
- Purity
- 98.80%
- Batch
- UKPL-9513
- Storage
- -20°C lyophilised, 2-8°C reconstituted
- Appearance
- White lyophilised powder
- Form
- Lyophilised powder
Certificate of Analysis
Supplier-reported analysis. Independent third-party verification pending.
- Batch
- UKPL-9513
- Purity
- 98.80%
- Specification
- ≥98.0%
- Method
- RP-HPLC
- Tested
- Sep 2026
Need the certificate for an earlier batch? Request an older CoA
Storage and Reconstitution
Move vials to the freezer on arrival and keep them dark and dry. Keep the solution in a light-protected container. Aliquot at reconstitution: thawing a whole 10mg stock again and again degrades the tryptophan in everything left. Tryptophan oxidation shows up as a new RP-HPLC peak after long or light-exposed storage.
Vials are sold on their own, without bacteriostatic water for mixing or other supplies.
How to reconstitute and handle
Let the vial reach room temperature. Wipe the stoppers of the peptide vial and the bacteriostatic water vial with an alcohol swab. Add the water slowly down the inside wall of the vial, not onto the powder. Swirl gently until the solution is clear and colourless, and do not shake or vortex. The N-terminal tryptophan is sensitive to light and oxidation, so work away from direct sunlight and fluorescent light. It also allows concentration checks by UV absorbance at 280 nm. Plan stock and aliquot volumes once, at reconstitution, so one vial serves the whole series.
- Keep solutions cold, minimise headspace and stopper-open time, and work under aseptic conditions.
For the full method, see the peptide reconstitution guide and the reconstitution calculator.
Research References
- Delta sleep-inducing peptide (DSIP): a still unresolved riddle (J Neurochem, 2006)
- Delta-sleep-inducing peptide (DSIP): a review (Neurosci Biobehav Rev, 1984)
Published research on DSIP is indexed on PubMed.
DSIP Price (UK)
DSIP is for sale in 2 vial sizes, priced from £19.99 for 5mg to £27.99 for 10mg. Every size ships from our UK facility, each with its own batch certificate. UK delivery is £4.50 by Royal Mail Tracked 24, free over £69.
| Vial | Price | Cost per mg | Availability |
|---|---|---|---|
| DSIP 5mg | £19.99 | £4.00 | In stock |
| DSIP 10mgThis page | £27.99 | £2.80Best value | In stock |
Prices are in GBP per vial and match the basket. See the FAQ for delivery and payment options, and quality & testing for how each batch is checked.
Frequently Asked Questions
What is the difference between DSIP 5mg and DSIP 10mg?
Only the amount of peptide per vial. Both hold the same nonapeptide with the same CAS number. The 10mg vial has twice the mass, so a long assay series needs fewer vials and fewer reconstitutions. The 5mg vial suits pilot work and single experiments. Each size is its own batch with its own certificate.
What does the research say about DSIP and sleep?
The findings are mixed. The 1977 work reported more delta and spindle EEG activity after intraventricular infusion in rabbits. Early human reports described effects on disturbed sleep (Schneider-Helmert and Schoenenberger, 1983). A double-blind study in 16 chronic insomniac patients found weak, partly confounded effects (Bes et al., 1992). No receptor or mechanism has been established.
What research areas beyond sleep involve DSIP?
Stress hormones and circadian rhythm. In vitro, DSIP inhibited corticotropin-releasing factor-induced ACTH secretion from rat anterior pituitary tissue (Okajima and Hertting, 1986). Graf and Kastin (Neurosci Biobehav Rev, 1984) catalogued effects on circadian and locomotor patterns. Kovalzon and Strekalova (2006) propose that a related DSIP-like peptide may explain the DSIP immunoreactivity found in brain tissue.
Is DSIP 10mg third-party tested?
Not yet. Batch UKPL-9513 carries a supplier certificate reporting 98.80% purity by HPLC. Independent third-party verification is pending, and the independent certificate will be added when complete.
Where can I buy DSIP 10mg in the UK?
UK Peptide Lab sells DSIP 10mg vials from UK stock, alongside the 5mg vial. Orders placed before 3pm on a working day are dispatched the same day by Royal Mail Tracked, and UK delivery is free over £69. It is sold for in-vitro research only, to buyers aged 18 or over.
Is your DSIP 10mg third-party tested?
Not yet. The certificate for batch UKPL-9513 is the supplier's analysis: 98.80% purity by HPLC and 10.02mg measured content. Independent third-party testing is pending, and that certificate will be published when complete. The 5mg DSIP vial is a separate batch with its own certificate.
What is DSIP 10mg used for in research?
Preclinical sleep, stress-hormone and circadian research. Studies look at delta-wave sleep architecture in rodents, ACTH regulation in pituitary tissue and locomotor rhythms. The 10mg vial suits longer assay series than the 5mg format.
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