Nootropic Peptides
Selank + Semax
10+10mg
Selank and Semax nootropic research blend, 10+10mg vial.
Content-verified · Supplier-reported analysis · Batch UKPL-9517 · View certificate
- Same-day dispatch before 3pm, Mon to Fri
- Add £34.01 more for free UK delivery
- Cold-chain shipping. Always. Dry-cold pack, Royal Mail Tracked 24
- Lost, damaged or wrong? Replaced free if you tell us within 48 hours.
- Research use only. For in-vitro laboratory research. Not for use in humans or animals, or in food, drugs or diagnostics. Not evaluated by the MHRA or FDA. The buyer is responsible for handling and regulatory compliance.
Bulk Pricing
Counted across your basket, any mix of products.
| Vials in basket | Discount | Per vial |
|---|---|---|
| 1 | None | £34.99 |
| 3-4 | 5% | £33.24 |
| 5-9 | 8% | £32.19 |
| 10-50 | 12% | £30.79 |
Bacteriostatic Water 10ml
Required to reconstitute lyophilised peptides.
What is Selank + Semax?
Selank + Semax 10+10mg is a pre-blended vial of two Russian-developed heptapeptides, 10mg of each, as lyophilised powder. Selank is Thr-Lys-Pro-Arg-Pro-Gly-Pro, an analogue of tuftsin. Semax is Met-Glu-His-Phe-Pro-Gly-Pro, an analogue of ACTH(4-10).
Full description
Both peptides come from the Institute of Molecular Genetics of the Russian Academy of Sciences and share one design. A short active fragment carries a C-terminal Pro-Gly-Pro tail that slows enzymatic breakdown. Both are registered medicines in Russia and hold no MHRA, EMA or FDA authorisation.
The two molecular weights are close, 751.9 and 813.9 g/mol, so this equal-mass blend is nearly equimolar: about 13.3 µmol of Selank to 12.3 µmol of Semax. The blend itself has no dedicated literature.
Selank + Semax Research Applications
- Selank and enkephalinases: it blocked breakdown of plasma enkephalin (IC50 15 µM), more potently than bacitracin or puromycin (Zozulya et al., 2001).
- Selank and gene expression: in rat frontal cortex it changed 45 of 84 neurotransmission genes within an hour, in step with GABA (Volkova et al., Front Pharmacol, 2016).
- Semax and neurotrophins: a 1.4-fold rise in hippocampal BDNF protein, with more trkB activation (Dolotov et al., Brain Res, 2006).
- Semax and ischaemia: smaller cortical infarcts in a rat model of focal ischaemia (Romanova et al., Bull Exp Biol Med, 2006).
Study details
The blend suits preclinical designs that would otherwise run both peptides from separate preparations, such as GABAergic and neurotrophin endpoints measured in one rodent cohort, or enzyme-inhibition assays. Its practical value is one reconstitution and one in-use window.
Selank + Semax vs the Components Alone
Each peptide has its own evidence base. Selank work centres on enkephalin-degrading enzymes and GABAergic gene expression. Semax work centres on BDNF and trkB signalling and ischaemia models. One study measured both side by side (Kost et al., Bioorg Khim, 2001). In human serum, Semax inhibited enkephalin-degrading enzymes with an IC50 of 10 µM and Selank with 20 µM. No controlled study has tested the co-formulated mixture. Once dissolved the ratio is fixed, so designs needing independent concentrations, a single-peptide control or attribution to one mechanism need the separate vials.
Research Overview
Selank adds Pro-Gly-Pro to tuftsin, the Thr-Lys-Pro-Arg tetrapeptide released from immunoglobulin G. Semax adds the same tail to Met-Glu-His-Phe, the core of ACTH(4-10). That shared stabilising chemistry is why the two are often studied side by side.
Kost and colleagues (Bioorg Khim, 2001) tested both against the enkephalin-degrading enzymes of human serum. Semax inhibited them with an IC50 of 10 µM and Selank with 20 µM, well ahead of puromycin. Their pentapeptide fragments were also active, while tri-, tetra- and hexapeptide fragments were not. Because these enzymes also break down other regulatory peptides, the authors proposed this inhibition as one mechanism for both compounds.
No controlled study has evaluated the two co-formulated, and no combined effect has been shown. Treat the blend as two compounds in one container and design controls accordingly. In-vitro laboratory research use only.
Product Specifications
- Components
- Selank 10mg + Semax 10mg (single vial, 20mg total peptide)
- Selank
- Thr-Lys-Pro-Arg-Pro-Gly-Pro, C₃₃H₅₇N₁₁O₉, 751.9 g/mol, CAS 129954-34-3
- Semax
- Met-Glu-His-Phe-Pro-Gly-Pro, C₃₇H₅₁N₉O₁₀S, 813.9 g/mol, CAS 80714-61-0
- Molar Ratio
- About 1.08 : 1 Selank to Semax (near-equimolar)
- Batch
- UKPL-9517
- Storage
- -20°C lyophilised, 2-8°C reconstituted
- Appearance
- White lyophilised powder (single vial)
- Form
- Lyophilised powder (co-formulated)
- CAS Number
- 129954-34-3 / 80714-61-0
- Molecular Weight
- 751.9 / 813.7 g/mol
Certificate of Analysis
Supplier-reported analysis. Independent third-party verification pending.
- Batch
- UKPL-9517
- Purity
- Content-verified
- Method
- RP-HPLC
- Tested
- Sep 2026
Need the certificate for an earlier batch? Request an older CoA
Storage and Reconstitution
Keep sealed vials at -20°C, away from light and moisture. After reconstitution, keep the solution at 2-8°C and use it within 4 weeks, or freeze single-use aliquots at -20°C. Both peptides share one reconstitution date, so aliquot at the start and avoid repeated freeze-thaw cycles.
Vials are sold on their own, without bacteriostatic water for mixing or other supplies.
How to reconstitute and handle
Treat the vial as one 20mg preparation, with the fill volume set by the concentration your protocol needs. Let the vial and the bacteriostatic water reach room temperature and swab both stoppers. Add the water slowly down the inside wall and swirl gently until dissolved. Do not shake or vortex. The solution should be clear and colourless. The N-terminal methionine of Semax oxidises in air and light, so keep stopper-open time short. Label the vial with fill volume, concentration and date.
- Check that the certificate reports each peptide separately, not one combined figure.
- Split reconstituted stock into single-use aliquots and avoid repeated freeze-thaw cycles.
For the full method, see the peptide reconstitution guide and the reconstitution calculator.
Research References
- Selank inhibits enkephalin-degrading enzymes (Zozulya et al., Bull Exp Biol Med, 2001)
- Selank affects gene expression in GABAergic neurotransmission (Volkova et al., Front Pharmacol, 2016)
- Semax regulates BDNF and trkB expression in rat hippocampus (Dolotov et al., Brain Res, 2006)
- Neuroprotective effects of Semax in experimental cerebral infarction (Romanova et al., Bull Exp Biol Med, 2006)
- Semax and Selank inhibit the enkephalin-degrading enzymes of human serum (Kost et al., Bioorg Khim, 2001)
Published research on Selank + Semax is indexed on PubMed.
Selank + Semax Price (UK)
Selank + Semax 10+10mg is for sale at £34.99 per vial, supplied from stock in the UK with a published supplier batch certificate. UK delivery is £4.50 by Royal Mail Tracked 24, free over £69.
| Vial | Price | Cost per mg | Availability |
|---|---|---|---|
| Selank + Semax 10+10mgThis page | £34.99 | £1.75 | In stock |
Prices are in GBP per vial and match the basket. See the FAQ for delivery and payment options, and quality & testing for how each batch is checked.
Frequently Asked Questions
What is in the Selank and Semax blend vial?
One vial with 10mg of Selank and 10mg of Semax, 20mg in total, lyophilised together. Selank is the tuftsin analogue Thr-Lys-Pro-Arg-Pro-Gly-Pro (751.9 g/mol, CAS 129954-34-3). Semax is the ACTH(4-10) analogue Met-Glu-His-Phe-Pro-Gly-Pro (813.9 g/mol, CAS 80714-61-0).
Is the Selank Semax blend a 1:1 mix?
Yes by mass, and nearly by moles. The molecular weights differ by only 62 g/mol, so 10mg of each is about 13.3 µmol of Selank against 12.3 µmol of Semax, a ratio near 1.08 to 1. That is unusual among equal-mass blends.
Why are Selank and Semax studied together?
They come from one design programme and share the same Pro-Gly-Pro stabilising tail. Their reported endpoints differ: enkephalinase inhibition and GABAergic gene expression for Selank, BDNF and ischaemia models for Semax. One study measured both side by side, finding each inhibits enkephalin-degrading enzymes in human serum (Kost et al., 2001).
Has the Selank Semax combination been studied as a combination?
No. No controlled study has tested the two co-formulated at this ratio, and no combined effect has been shown. Every mechanistic finding comes from work on one peptide alone, or on each measured separately. Treat the blend as two compounds in one container.
Where can I buy a Selank Semax blend in the UK?
You can buy the Selank + Semax 10+10mg blend online from UK Peptide Lab, batch UKPL-9517, with its supplier-reported certificate published on the product page. Orders placed before 3pm UK time on a working day are dispatched the same day. Single 10mg vials of each peptide are also stocked. Buyers must be 18 or over.
Where can I buy a Selank and Semax blend in the UK?
UK Peptide Lab has the Selank + Semax 10+10mg blend for sale from UK stock, batch UKPL-9517. Orders placed before 3pm UK time on a working day are dispatched the same day, and UK Royal Mail Tracked delivery is free over £69.
Is your Selank Semax blend third-party tested?
Not yet. The certificate for batch UKPL-9517 is a supplier-reported analysis, published on the product page. It reports each peptide separately: 9.98mg Selank and 10.20mg Semax. Independent third-party verification is pending.
Should I buy the blend or the individual Selank and Semax vials?
Buy the blend for combined designs at a fixed 1:1 mass ratio, from one vial and one reconstitution. Buy the individual 10mg vials to vary the ratio, run a single-peptide control or attribute an effect to one molecule. Both formats are stocked, each with its own batch.
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