Peptides
SNAP-8
10mg
Acetyl octapeptide. Neuromuscular signalling research.
98.92% purity · Supplier-reported analysis · Batch UKPL-9511 · View certificate
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- Add £49.01 more for free UK delivery
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- Research use only. For in-vitro laboratory research. Not for use in humans or animals, or in food, drugs or diagnostics. Not evaluated by the MHRA or FDA. The buyer is responsible for handling and regulatory compliance.
Bulk Pricing
Counted across your basket, any mix of products.
| Vials in basket | Discount | Per vial |
|---|---|---|
| 1 | None | £19.99 |
| 3-4 | 5% | £18.99 |
| 5-9 | 8% | £18.39 |
| 10-50 | 12% | £17.59 |
Bacteriostatic Water 10ml
Required to reconstitute lyophilised peptides.
What is SNAP-8?
SNAP-8 is an acetyl octapeptide (Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2) designed to extend the sequence of acetyl hexapeptide-3. Research has examined its reported inhibition of SNARE complex formation and catecholamine release in models of neuromuscular signalling, with applications studied primarily in cosmetic science.
Full description
SNAP-8, catalogued as acetyl octapeptide-3, has the sequence Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH₂. Its formula is C₄₁H₇₀N₁₆O₁₆S, its molecular weight about 1075 g/mol and its CAS number 868844-74-0. It was designed for cosmetic science as an extension of acetyl hexapeptide-3 (Argireline), with alanine and aspartate added at the C-terminus. It is a cosmetic ingredient, not a medicine.
Both peptides copy the N-terminal region of SNAP-25, the 25 kDa protein that gives two helices to the neuronal SNARE complex. That four-helix complex drives calcium-dependent vesicle fusion, and botulinum neurotoxin A cleaves SNAP-25 at the neuromuscular junction. Each SNAP-8 10mg vial holds white lyophilised powder.
SNAP-8 Research Applications
- SNARE assembly: Blanes-Mira and colleagues (J Neurochem, 2004) reported that peptides patterned on the SNAP-25 N-terminus are potent inhibitors of SNARE complex formation.
- Where it acts: in that study SNARE complex formation needed SNAP-25 residues 22 to 44, and inhibition tracked each peptide's tendency to form an alpha-helix. SNAP-8 covers residues 12 to 19 and was not tested there.
- Exocytosis: the same peptides inhibited calcium-dependent exocytosis from detergent-permeabilised excitable cells.
- C-terminal comparison: Gutierrez and colleagues (J Biol Chem, 1997) showed that a 20-residue peptide from the SNAP-25 C-terminus blocked vesicle docking in chromaffin cells, mimicking botulinum toxin A.
- Formulation analysis: published methods quantify the peptide in cosmetic formulations (Ji et al., J Anal Sci Technol, 2020).
Study details
Typical in-vitro work covers SNARE assembly assays, competition against native SNAP-25 and syntaxin, and exocytosis models. In cosmetic science it belongs to the neurotransmitter-inhibitor peptides, one of the classes catalogued by Pintea and colleagues (Biomolecules, 2025). Poor membrane permeability is a known limit of that class. The mechanistic literature is small and comes mostly from one group.
SNAP-8 vs Argireline (Acetyl Hexapeptide-3)
The two share six residues. Argireline is Ac-Glu-Glu-Met-Gln-Arg-Arg-NH₂, about 889 g/mol. SNAP-8 adds Ala-Asp at the C-terminus, reaching about 1075 g/mol and matching SNAP-25 residues 12 to 19. Both are proposed to compete with native SNAP-25 for SNARE complex assembly. The published record separates them. The hexapeptide has its own paper, with in-vitro release data and a volunteer study (Blanes-Mira et al., Int J Cosmet Sci, 2002). It inhibited neurotransmitter release with a potency similar to botulinum toxin A, but with much lower efficacy. The octapeptide has no comparable paper of its own; its case rests on the same group's work on N-terminal SNAP-25 peptides (J Neurochem, 2004) and on manufacturer dossiers. Head-to-head data are sparse, so the Ala-Asp extension is the variable under test.
Research Overview
Argireline came out of a rational design programme at the Blanes-Mira group, and SNAP-8 extends its sequence. Peptides that mimic the SNAP-25 N-terminus are proposed to compete with the native protein for a place in the SNARE complex, which would reduce neurotransmitter release.
The octapeptide has no independent, randomised cosmetic trial of its own. Most efficacy figures quoted for it trace to manufacturer technical dossiers, not journals. Cosmetic figures quoted online usually come from the hexapeptide paper (Blanes-Mira et al., Int J Cosmet Sci, 2002), not from SNAP-8.
Product Specifications
- Molecular Formula
- C₄₁H₇₀N₁₆O₁₆S
- Molecular Weight
- ≈1075.2 g/mol
- CAS Number
- 868844-74-0
- Sequence
- Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH₂
- Purity
- 98.92%
- Batch
- UKPL-9511
- Storage
- -20°C lyophilised, 2-8°C reconstituted
- Appearance
- White lyophilised powder
- Form
- Lyophilised powder
Certificate of Analysis
Supplier-reported analysis. Independent third-party verification pending.
- Batch
- UKPL-9511
- Purity
- 98.92%
- Specification
- ≥98.0%
- Method
- RP-HPLC
- Tested
- Sep 2026
Need the certificate for an earlier batch? Request an older CoA
Storage and Reconstitution
Move vials to the freezer on arrival; the powder tolerates short transit at room temperature. Oxidation of methionine 3 is the main risk in solution. Keep vials tightly sealed with little headspace, protect them from light, and freeze single-use aliquots for longer storage. Discard any solution that turns cloudy.
Vials are sold on their own, without bacteriostatic water for mixing or other supplies.
How to reconstitute and handle
Let the vial reach room temperature. Wipe the stoppers of the peptide vial and the bacteriostatic water vial with an alcohol swab. Add the water slowly down the inside wall of the vial, not onto the powder. Swirl gently until the solution is clear and colourless, and do not shake or vortex. The methionine at position three oxidises easily, so avoid drawing in extra air and re-seal promptly. Label the vial with the date.
- Keep solutions cold, minimise headspace and stopper-open time, and use single-use aliquots instead of opening one vial repeatedly.
- Work aseptically with alcohol-swabbed stoppers and sterile syringes, and avoid repeated freeze-thaw.
For the full method, see the peptide reconstitution guide and the reconstitution calculator.
Research References
- Small peptides patterned after the N-terminus domain of SNAP25 inhibit SNARE complex assembly and regulated exocytosis (Blanes-Mira et al., J Neurochem, 2004)
- A synthetic hexapeptide (Argireline) with antiwrinkle activity (Blanes-Mira et al., Int J Cosmet Sci, 2002)
Published research on SNAP-8 is indexed on PubMed.
SNAP-8 Price (UK)
SNAP-8 10mg is for sale at £19.99 per vial, supplied from stock in the UK with a published supplier batch certificate. UK delivery is £4.50 by Royal Mail Tracked 24, free over £69.
| Vial | Price | Cost per mg | Availability |
|---|---|---|---|
| SNAP-8 10mgThis page | £19.99 | £2.00 | In stock |
Prices are in GBP per vial and match the basket. See the FAQ for delivery and payment options, and quality & testing for how each batch is checked.
Frequently Asked Questions
How does SNAP-8 relate to botulinum toxin?
Both act on the same protein, SNAP-25, but in different ways. Botulinum neurotoxin A cleaves SNAP-25 and disables the SNARE complex. SNAP-8 copies part of the SNAP-25 N-terminus, and peptides of this type inhibit SNARE complex formation in vitro (Blanes-Mira et al., J Neurochem, 2004). It is a research model of that pathway, not a toxin and not a medicine.
What is the difference between SNAP-8 and Argireline?
Two amino acids. Argireline is Ac-Glu-Glu-Met-Gln-Arg-Arg-NH₂, about 889 g/mol. SNAP-8 adds alanine and aspartate at the C-terminus, about 1075 g/mol (CAS 868844-74-0). Argireline has its own published study (Blanes-Mira et al., Int J Cosmet Sci, 2002). SNAP-8 has little published data of its own, and head-to-head comparisons are sparse.
What is SNAP-8 used for in research?
In-vitro research on SNAP-25 and the neuronal SNARE complex. Typical assays are SNARE assembly and calcium-dependent exocytosis in permeabilised cells, following Blanes-Mira and colleagues (J Neurochem, 2004). Applied work is mainly in cosmetic science, where it serves as a model compound.
Is SNAP-8 legal to buy in the UK?
Yes, as a research chemical. SNAP-8 is not a controlled drug, and it may be bought and held in the UK for in-vitro laboratory use. It is not a licensed medicine, so under the Human Medicines Regulations 2012 it cannot be sold or supplied for human consumption. Buyers must be 18 or over and confirm research-only use at checkout.
Where can I buy SNAP-8 in the UK?
UK Peptide Lab sells SNAP-8 10mg vials from UK stock. Orders placed before 3pm on a working day are dispatched the same day by Royal Mail Tracked, and UK delivery is free over £69. It is sold for in-vitro research only, to buyers aged 18 or over.
Is your SNAP-8 tested?
Yes, by the supplier. Their analysis of batch UKPL-9511 reports 98.92% purity by RP-HPLC and 9.89mg measured content against the 10mg label. Independent third-party testing is pending. The certificate is published with this listing, and its batch number matches the one printed on the vial.
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