Peptides
Thymosin Alpha-1
10mg
28-residue thymic peptide. Immune-modulation research.
99.76% purity · Supplier-reported analysis · Batch UKPL-9504 · View certificate
- Same-day dispatch before 3pm, Mon to Fri
- Add £24.01 more for free UK delivery
- Cold-chain shipping. Always. Dry-cold pack, Royal Mail Tracked 24
- Lost, damaged or wrong? Replaced free if you tell us within 48 hours.
- Research use only. For in-vitro laboratory research. Not for use in humans or animals, or in food, drugs or diagnostics. Not evaluated by the MHRA or FDA. The buyer is responsible for handling and regulatory compliance.
Bulk Pricing
Counted across your basket, any mix of products.
| Vials in basket | Discount | Per vial |
|---|---|---|
| 1 | None | £44.99 |
| 3-4 | 5% | £42.74 |
| 5-9 | 8% | £41.39 |
| 10-50 | 12% | £39.59 |
Bacteriostatic Water 10ml
Required to reconstitute lyophilised peptides.
What is Thymosin Alpha-1?
Thymosin alpha-1 is a 28 amino acid peptide first isolated from thymic tissue, corresponding to the N-terminal region of prothymosin alpha. Research has examined its reported effects on T-cell maturation and function, dendritic cell activity and cytokine regulation, and it holds pharmaceutical licences in several countries for immunomodulatory indications.
Full description
Thymosin alpha-1 (TA1, thymosin α1), INN thymalfasin, is a 28-residue peptide with an acetylated N-terminus. The sequence is Ac-SDAAVDTSSEITTKDLKEKKEVVEEAEN, molecular weight 3108.28 g/mol, CAS 62304-98-7. Goldstein and colleagues (Proc Natl Acad Sci USA, 1977) isolated it from calf thymosin fraction 5 and described a heat-stable, highly acidic peptide. It matches the N-terminal 28 residues of prothymosin alpha.
The sequence has no cysteine or methionine, so there are no disulfides and no methionine oxidation to manage. Unlike most research peptides, TA1 has a pharmaceutical history. As Zadaxin it is a prescription medicine in more than 35 countries, including for chronic hepatitis B. It has never been licensed in the UK, the EU or the United States. Each Thymosin Alpha-1 10mg vial holds white lyophilised powder.
Thymosin Alpha-1 Research Applications
- Dendritic cells: in mouse dendritic cells exposed to Aspergillus fumigatus, TA1 drove maturation and IL-12 production through MyD88-dependent Toll-like receptor signalling (Romani et al., Blood, 2004).
- Infection models: in the same study, TA1 protected highly susceptible transplanted mice from aspergillosis.
- Immune markers: Garaci (Ann N Y Acad Sci, 2007) reviews increased MHC class I and Toll-like receptor expression and cytokine production, and combination work with cytokines and chemotherapy.
- Oncology: a 2025 retrospective analysis of 386 patients with platinum-resistant recurrent ovarian cancer studied TA1 alongside PD-1 or PD-L1 inhibitors and chemotherapy (Wang et al., Cancer Manag Res, 2025).
Study details
Typical in-vitro work covers dendritic cell maturation, Toll-like receptor signalling and cytokine assays. Much of the older immunology literature is small and mixed, and the recent oncology data are largely retrospective.
Thymosin Alpha-1 vs TB-500
The two share a name and a tissue of origin, and little else. Thymosin alpha-1 is a 28-residue, N-acetylated peptide of 3108.28 g/mol, studied in immunology: dendritic cell signalling and cytokines. TB-500 is the research-market name for synthetic thymosin beta-4, a 43-residue actin-binding protein of 4963.4 g/mol. Its literature concerns actin, cell migration and angiogenesis, built around the seven-residue LKKTETQ actin-binding motif (Philp et al., FASEB J, 2003). Choosing between them means choosing between an immunology tool and a cytoskeletal one.
Research Overview
Goldstein and colleagues (1977) identified TA1 as one of several peptides in thymosin fraction 5. It is strongly acidic, with nine acidic residues against four lysines.
Zadaxin's licence rests on trials in chronic hepatitis B. One randomised trial allocated 98 patients to three groups (Chien et al., Hepatology, 1998), and Camerini and Garaci (Expert Opin Biol Ther, 2015) review the history. No thymosin alpha-1 product is an approved medicine in the UK. Our 5mg vial holds the same molecule for smaller designs.
Product Specifications
- CAS Number
- 62304-98-7
- Molecular Weight
- 3108.28 g/mol
- Molecular Formula
- C₁₂₉H₂₁₅N₃₃O₅₅
- Sequence
- Ac-SDAAVDTSSEITTKDLKEKKEVVEEAEN
- Purity
- 99.76% (HPLC, supplier-reported)
- Batch
- UKPL-9504
- Storage
- -20°C lyophilised, 2-8°C reconstituted
- Appearance
- White lyophilised powder
- Form
- Lyophilised powder
Certificate of Analysis
Supplier-reported analysis. Independent third-party verification pending.
- Batch
- UKPL-9504
- Purity
- 99.76%
- Specification
- ≥98.0%
- Method
- RP-HPLC
- Tested
- Sep 2026
Need the certificate for an earlier batch? Request an older CoA
Storage and Reconstitution
Move vials to the freezer on arrival and keep them dark and dry. Deamidation of the C-terminal asparagine speeds up at higher pH and temperature. Keep the solution cold, limit time at room temperature, keep it away from alkaline solutions, and freeze single-use aliquots for longer storage.
Vials are sold on their own, without bacteriostatic water for mixing or other supplies.
How to reconstitute and handle
Let the vial reach room temperature. Wipe the stoppers of the peptide vial and the bacteriostatic water vial with an alcohol swab. Add the water slowly down the inside wall of the vial, not onto the powder. Swirl gently until the solution is clear and colourless, and do not shake or vortex. The chain ends in asparagine, a residue that can deamidate in solution, so reconstitute promptly and refrigerate. Label the vial with the date.
- No disulfide or methionine handling is needed. Work aseptically with sterile syringes and alcohol-swabbed stoppers.
- Keep reconstituted solutions cold and use single-use aliquots instead of opening one vial repeatedly.
For the full method, see the peptide reconstitution guide and the reconstitution calculator.
Research References
- Thymosin alpha1: isolation and sequence analysis of an immunologically active thymic polypeptide (Goldstein et al., Proc Natl Acad Sci USA, 1977)
- Thymosin alpha 1 activates dendritic cells for antifungal Th1 resistance through toll-like receptor signaling (Romani et al., Blood, 2004)
Published research on Thymosin Alpha-1 is indexed on PubMed.
Thymosin Alpha-1 Price (UK)
Thymosin Alpha-1 is for sale in 2 vial sizes, priced from £29.99 for 5mg to £44.99 for 10mg. Every size ships from our UK facility, each with its own batch certificate. UK delivery is £4.50 by Royal Mail Tracked 24, free over £69.
| Vial | Price | Cost per mg | Availability |
|---|---|---|---|
| Thymosin Alpha-1 10mgThis page | £44.99 | £4.50Best value | Low stock |
| Thymosin Alpha-1 5mg | £29.99 | £6.00 | In stock |
Prices are in GBP per vial and match the basket. See the FAQ for delivery and payment options, and quality & testing for how each batch is checked.
Frequently Asked Questions
How does Thymosin Alpha-1 work?
Mainly through Toll-like receptor signalling in antigen-presenting cells, in the published work. Romani and colleagues (Blood, 2004) reported that TA1 matured dendritic cells and drove IL-12 production through MyD88-dependent Toll-like receptor pathways. Garaci (Ann N Y Acad Sci, 2007) reviews increased MHC class I and Toll-like receptor expression. It is not an approved medicine in the UK.
What is the difference between Thymosin Alpha-1 and TB-500?
They are unrelated peptides that share a name. Thymosin alpha-1 is a 28-residue acetylated peptide (3108.28 g/mol) studied for Toll-like receptor signalling in dendritic cells. TB-500 is synthetic thymosin beta-4, a 43-residue actin-binding protein (4963.4 g/mol, CAS 77591-33-4) studied for cell migration. They come from different parent proteins and have separate literatures.
What is Thymosin Alpha-1 used for in research?
Immunology. Studies look at dendritic cell maturation, Toll-like receptor signalling and cytokine production (Romani et al., Blood, 2004; Garaci, Ann N Y Acad Sci, 2007). Recent oncology papers study it alongside immune checkpoint inhibitors (Wang et al., Cancer Manag Res, 2025). It is sold here for in-vitro research only.
Is Thymosin Alpha-1 a licensed medicine?
Outside the UK, in part. As Zadaxin, thymosin alpha-1 (thymalfasin) is a prescription medicine in more than 35 countries, with indications including chronic hepatitis B. It has never been licensed in the UK, the EU or the United States. This product is for in-vitro research only, not for human or veterinary use.
Where can I buy Thymosin Alpha-1 in the UK?
UK Peptide Lab sells Thymosin Alpha-1 in 10mg and 5mg vials from UK stock. Orders placed before 3pm on a working day are dispatched the same day by Royal Mail Tracked, and UK delivery is free over £69. It is sold for in-vitro research only, to buyers aged 18 or over.
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