Peptides
Thymosin Alpha-1
5mg
28-residue thymic peptide, 5mg vial. Immune-modulation research.
99.48% purity · Supplier-reported analysis · Batch UKPL-9508 · View certificate
- Same-day dispatch before 3pm, Mon to Fri
- Add £39.01 more for free UK delivery
- Cold-chain shipping. Always. Dry-cold pack, Royal Mail Tracked 24
- Lost, damaged or wrong? Replaced free if you tell us within 48 hours.
- Research use only. For in-vitro laboratory research. Not for use in humans or animals, or in food, drugs or diagnostics. Not evaluated by the MHRA or FDA. The buyer is responsible for handling and regulatory compliance.
Bulk Pricing
Counted across your basket, any mix of products.
| Vials in basket | Discount | Per vial |
|---|---|---|
| 1 | None | £29.99 |
| 3-4 | 5% | £28.49 |
| 5-9 | 8% | £27.59 |
| 10-50 | 12% | £26.39 |
Bacteriostatic Water 10ml
Required to reconstitute lyophilised peptides.
What is Thymosin Alpha-1?
Thymosin alpha-1 is a 28 amino acid peptide first isolated from thymic tissue, corresponding to the N-terminal region of prothymosin alpha. Research has examined its reported effects on T-cell maturation and function, dendritic cell activity and cytokine regulation, and it holds pharmaceutical licences in several countries for immunomodulatory indications. This 5mg presentation is the lower-mass research format of our 10mg vial.
Full description
Thymosin Alpha-1 5mg holds half the lyophilised mass of our 10mg vial, in the same single-vial glass format. The molecule is identical: thymosin alpha-1 (TA1, INN thymalfasin), the 28-residue N-acetylated peptide Ac-SDAAVDTSSEITTKDLKEKKEVVEEAEN, 3108.28 g/mol, CAS 62304-98-7. Goldstein and colleagues (Proc Natl Acad Sci USA, 1977) first isolated it from calf thymus.
The 5mg size suits pilot runs, screening work and designs that need less total peptide. At the same fill volume it gives half the concentration of the 10mg vial.
Thymosin Alpha-1 Research Applications
- Dendritic cells: in mouse dendritic cells exposed to Aspergillus fumigatus, TA1 drove maturation and IL-12 production through MyD88-dependent Toll-like receptor signalling (Romani et al., Blood, 2004).
- Immune markers: Garaci (Ann N Y Acad Sci, 2007) reviews increased MHC class I and Toll-like receptor expression and cytokine production.
- Oncology: recent retrospective work studies TA1 alongside PD-1 or PD-L1 inhibitors and chemotherapy in platinum-resistant recurrent ovarian cancer (Wang et al., Cancer Manag Res, 2025).
Study details
Applications match the 10mg vial: dendritic cell maturation, Toll-like receptor signalling and cytokine assays. Vial size changes logistics, not endpoints. Much of the older immunology literature is small and mixed, and the oncology data are largely retrospective.
Thymosin Alpha-1 5mg vs 10mg
Both vials hold the same molecule, so this is a logistics choice. Each size is its own batch with its own certificate: the 5mg batch is UKPL-9508. At the same fill volume the 5mg vial gives half the concentration, so scale volumes instead of carrying them over. The 10mg vial costs less per milligram and puts twice the work under one batch. The 5mg vial costs less up front, is used up sooner once reconstituted, and leaves less spare material if a design changes. A large study run on 5mg vials spans more batches, so track batch numbers across the dataset.
Research Overview
The molecule is strongly acidic, with nine acidic residues against four lysines, and it has no cysteine or methionine. Goldstein and colleagues (1977) identified it as one of several peptides in calf thymosin fraction 5.
As Zadaxin, thymalfasin is a prescription medicine in more than 35 countries, with indications including chronic hepatitis B. The trials behind that licence include a randomised trial of 98 patients (Chien et al., Hepatology, 1998), and Camerini and Garaci (Expert Opin Biol Ther, 2015) review the history. It has never been licensed in the UK, the EU or the United States.
Product Specifications
- CAS Number
- 62304-98-7
- Molecular Weight
- 3108.28 g/mol
- Molecular Formula
- C₁₂₉H₂₁₅N₃₃O₅₅
- Sequence
- Ac-SDAAVDTSSEITTKDLKEKKEVVEEAEN
- Vial Content
- 5mg
- Purity
- 99.48% (HPLC, supplier-reported)
- Batch
- UKPL-9508
- Storage
- -20°C lyophilised, 2-8°C reconstituted
- Appearance
- White lyophilised powder
- Form
- Lyophilised powder
Certificate of Analysis
Supplier-reported analysis. Independent third-party verification pending.
- Batch
- UKPL-9508
- Purity
- 99.48%
- Specification
- ≥98.0%
- Method
- RP-HPLC
- Tested
- Sep 2026
Need the certificate for an earlier batch? Request an older CoA
Storage and Reconstitution
Move vials to the freezer on arrival and keep them dark and dry. The C-terminal asparagine can deamidate in solution, faster at higher pH and temperature. Keep the solution cold, keep sessions short, and freeze single-use aliquots for longer storage.
Vials are sold on their own, without bacteriostatic water for mixing or other supplies.
How to reconstitute and handle
Let the vial reach room temperature. Wipe the stoppers of the peptide vial and the bacteriostatic water vial with an alcohol swab. Add the water slowly down the inside wall of the vial, not onto the powder. Swirl gently until the solution is clear and colourless, and do not shake or vortex. Set the fill volume from your target concentration: 5mg reaches half the concentration of 10mg at the same volume. We give no fill volume and no dosing information, because that is a protocol decision.
- No disulfide or methionine handling is needed. Work aseptically with sterile syringes and alcohol-swabbed stoppers.
- Keep reconstituted solutions cold and use single-use aliquots instead of opening one vial repeatedly.
For the full method, see the peptide reconstitution guide and the reconstitution calculator.
Research References
- Thymosin alpha1: isolation and sequence analysis of an immunologically active thymic polypeptide (Goldstein et al., Proc Natl Acad Sci USA, 1977)
- Thymosin alpha 1 activates dendritic cells for antifungal Th1 resistance through toll-like receptor signaling (Romani et al., Blood, 2004)
- Thymosin alpha1: a historical overview (Garaci, Ann N Y Acad Sci, 2007)
Published research on Thymosin Alpha-1 is indexed on PubMed.
Thymosin Alpha-1 Price (UK)
Thymosin Alpha-1 is for sale in 2 vial sizes, priced from £29.99 for 5mg to £44.99 for 10mg. Every size ships from our UK facility, each with its own batch certificate. UK delivery is £4.50 by Royal Mail Tracked 24, free over £69.
| Vial | Price | Cost per mg | Availability |
|---|---|---|---|
| Thymosin Alpha-1 10mg | £44.99 | £4.50Best value | Low stock |
| Thymosin Alpha-1 5mgThis page | £29.99 | £6.00 | In stock |
Prices are in GBP per vial and match the basket. See the FAQ for delivery and payment options, and quality & testing for how each batch is checked.
Frequently Asked Questions
What is the difference between the Thymosin Alpha-1 5mg and 10mg vials?
Only the mass of lyophilised peptide per vial. Both hold the same 28-residue thymosin alpha-1 at 3108.28 g/mol, in the same glass vial format. At an equal fill volume the 5mg vial reconstitutes to half the concentration. Each size is its own batch with its own certificate, so the 5mg batch UKPL-9508 does not borrow the 10mg figures.
How does Thymosin Alpha-1 work?
Mainly through Toll-like receptor signalling in antigen-presenting cells, in the published work. Romani and colleagues (Blood, 2004) reported that TA1 matured dendritic cells and drove IL-12 production through MyD88-dependent Toll-like receptor pathways. Garaci (Ann N Y Acad Sci, 2007) reviews increased MHC class I and Toll-like receptor expression. It is not an approved medicine in the UK.
What is the difference between Thymosin Alpha-1 and TB-500?
They are unrelated peptides that share a name. Thymosin alpha-1 is a 28-residue acetylated peptide (3108.28 g/mol) studied for Toll-like receptor signalling in dendritic cells. TB-500 is synthetic thymosin beta-4, a 43-residue actin-binding protein (4963.4 g/mol, CAS 77591-33-4) studied for cell migration. They come from different parent proteins and have separate literatures.
Is Thymosin Alpha-1 a licensed medicine?
Outside the UK, in part. As Zadaxin, thymosin alpha-1 (thymalfasin) is a prescription medicine in more than 35 countries, with indications including chronic hepatitis B. It has never been licensed in the UK, the EU or the United States. This product is for in-vitro research only, not for human or veterinary use.
Where can I buy Thymosin Alpha-1 5mg in the UK?
UK Peptide Lab sells Thymosin Alpha-1 5mg from UK stock, alongside the 10mg vial. Orders placed before 3pm on a working day are dispatched the same day by Royal Mail Tracked, and UK delivery is free over £69. Each size has its own batch and certificate. It is sold for in-vitro research only, to buyers aged 18 or over.
What is the difference between the 5mg and 10mg vials?
Only the mass of peptide. Both hold the same 28-residue acetylated sequence, Ac-SDAAVDTSSEITTKDLKEKKEVVEEAEN, at 3108.28 g/mol. The 5mg vial has half the content, so it gives half the concentration at a given fill volume. It suits designs that need less total peptide.
Is your Thymosin Alpha-1 supplier-tested, with independent verification in progress?
Yes. The supplier's analysis of the 5mg batch, UKPL-9508, reports 99.48% purity by HPLC and 5.40mg measured content against the 5mg label. Independent third-party testing is pending. The certificate is published with this listing, and its batch number matches the one on the vial. The 10mg vial has its own certificate.
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