Growth Hormone Secretagogues
CJC-1295
5mg
Synthetic GHRH analogue. 29 amino acid modified sequence.
98.450% purity · Third-party tested · Batch UKPL-9425 · View certificate
- Same-day dispatch before 3pm, Mon to Fri
- Add £43.01 more for free UK delivery
- Cold-chain shipping. Always. Dry-cold pack, Royal Mail Tracked 24
- Lost, damaged or wrong? Replaced free if you tell us within 48 hours.
- Research use only. For in-vitro laboratory research. Not for use in humans or animals, or in food, drugs or diagnostics. Not evaluated by the MHRA or FDA. The buyer is responsible for handling and regulatory compliance.
Bulk Pricing
Counted across your basket, any mix of products.
| Vials in basket | Discount | Per vial |
|---|---|---|
| 1 | None | £25.99 |
| 3-4 | 5% | £24.69 |
| 5-9 | 8% | £23.91 |
| 10-50 | 12% | £22.87 |
CJC-1295 + Ipamorelin 5+5mg
Pre-blended GHRH + GHRP research peptide vial. CJC-1295 (no DAC) and Ipamorelin combined.
All components in one lyophilised vial, with one certificate.
What is CJC-1295?
CJC-1295 without DAC, also sold as modified GRF (1-29) or Mod GRF 1-29, is a 29 amino acid analogue of growth hormone releasing hormone. It acts at the GHRH receptor on pituitary somatotrophs. We supply it as a 5mg vial of lyophilised powder.
Full description
Compared with native GHRH (1-29), CJC-1295 without DAC carries four substitutions: D-Ala2, Gln8, Ala15 and Leu27. The formula is C₁₅₂H₂₅₂N₄₄O₄₂, the molecular weight 3367.9 g/mol and the CAS number 863288-34-0.
Plasma dipeptidyl peptidase IV inactivates native GHRH by cutting the bond between residues 2 and 3. A D-amino acid at position 2 blocks that cut (Frohman et al., J Clin Invest, 1989). The code CJC-1295 first named ConjuChem's DAC-bearing molecule. Sellers now use it for both forms, so check the mass on the certificate.
CJC-1295 Research Applications
CJC-1295 without DAC is used in GHRH receptor pharmacology, somatotroph cell studies and GH release kinetics. It is the usual GHRH-side partner in two-receptor designs with a ghrelin-receptor agonist such as ipamorelin. The human studies cited here used the DAC form, so check which molecule a paper used.
CJC-1295 No-DAC vs CJC-1295 DAC
Both share the tetrasubstituted GRF (1-29) chain and act at the GHRH receptor. The DAC form adds a C-terminal lysine carrying a maleimidopropionamide group, which binds Cys34 of serum albumin. In rats that conjugate was still in plasma after 72 hours (Jetté et al., Endocrinology, 2005).
In healthy adults the DAC form had a half-life of 5.8 to 8.1 days (Teichman et al., 2006). GH secretion stayed pulsatile under that continuous stimulation, with trough levels up 7.5-fold (Ionescu and Frohman, 2006). The no-DAC form has no albumin anchor, so it suits short, pulse-like stimulation. At 3647.2 against 3367.9 g/mol, mass spectrometry tells the two apart.
Research Overview
Frohman and colleagues (J Clin Invest, 1989) found that plasma breaks GHRH down mainly through dipeptidyl peptidase IV at the 2-3 bond. Trypsin-like enzymes cut it to a lesser extent, at positions 11-12. D-amino acids at position 1 or 2 blocked the DPP IV step. Modified GRF (1-29) has D-Ala at position 2.
Jetté and colleagues at ConjuChem (Endocrinology, 2005) built CJC-1295 by adding a maleimido lysine to that tetrasubstituted chain. In rats it gave a 4-fold larger GH area under the curve over 2 hours than hGRF (1-29). Much of the literature quoted for CJC-1295 without DAC is about the DAC molecule, including the Teichman trial. Neither form holds a marketing authorisation.
Product Specifications
- Molecular Formula
- C₁₅₂H₂₅₂N₄₄O₄₂
- Molecular Weight
- 3367.9 g/mol
- Sequence
- Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH₂
- Purity
- 98.450% (RP-HPLC)
- Batch
- UKPL-9425
- Form
- White to off-white lyophilised powder
- CAS Number
- 863288-34-0
Certificate of Analysis
Third-party tested
- Batch
- UKPL-9425
- Purity
- 98.450%
- Specification
- ≥98.0%
- Method
- RP-HPLC
- Lab
- Janoshik Analytical
- Tested
- Sep 2026
Need the certificate for an earlier batch? Request an older CoA
Storage and Reconstitution
Store CJC-1295 powder at -20°C, away from light and moisture, for up to 24 months. After reconstitution, keep the solution at 2-8°C and use it within 4 weeks. For longer storage, freeze single-use aliquots at -20°C and avoid repeated freeze-thaw cycles.
Vials are sold on their own, without bacteriostatic water for mixing or other supplies.
How to reconstitute and handle
Let the vial and the bacteriostatic water reach room temperature and swab both stoppers with alcohol. Add the water slowly down the inside wall of the vial and swirl gently until dissolved. Do not shake or vortex. The solution should be clear and colourless.
- Leu27 replaces the methionine of native GHRH, so the chain has no methionine to oxidise.
- At 3367.9 g/mol, 5mg of CJC-1295 is 1.48 µmol.
For the full method, see the peptide reconstitution guide and the reconstitution calculator.
Research References
- Prolonged stimulation of GH and IGF-I secretion by CJC-1295 in healthy adults (Teichman et al., J Clin Endocrinol Metab, 2006; DAC form)
- Systemic and local regulation of the growth plate (van der Eerden et al., Endocr Rev, 2003)
- Dipeptidylpeptidase IV and trypsin-like degradation of GHRH in plasma (Frohman et al., J Clin Invest, 1989)
- hGRF(1-29)-albumin bioconjugates: identification of CJC-1295 as a long-lasting GRF analog (Jetté et al., Endocrinology, 2005)
- Pulsatile GH secretion persists during continuous stimulation by CJC-1295 (Ionescu and Frohman, J Clin Endocrinol Metab, 2006)
- GH-releasing peptide and GHRH in normal men (Bowers et al., J Clin Endocrinol Metab, 1990)
Published research on CJC-1295 is indexed on PubMed. See our full UK buyer's guide for CJC-1295.
CJC-1295 Price (UK)
CJC-1295 5mg is for sale at £25.99 per vial, supplied from stock in the UK with a published third-party HPLC certificate. UK delivery is £4.50 by Royal Mail Tracked 24, free over £69.
| Vial | Price | Cost per mg | Availability |
|---|---|---|---|
| CJC-1295 5mgThis page | £25.99 | £5.20 | In stock |
Prices are in GBP per vial and match the basket. See the FAQ for delivery and payment options, and quality & testing for how each batch is checked.
Frequently Asked Questions
What is CJC-1295 (Mod GRF 1-29) used for in research?
It stimulates the GHRH receptor without the albumin binding of the DAC form. Pituitary cell and animal studies use it to trigger growth hormone release in discrete pulses.
What is the difference between CJC-1295 with DAC and without DAC?
The DAC form carries an extra lysine with a maleimide group that binds serum albumin. The no-DAC form does not. That anchor gave the DAC form a half-life of 5.8 to 8.1 days in healthy adults (Teichman et al., 2006). Their molecular weights are 3647.2 and 3367.9 g/mol.
Can CJC-1295 and Ipamorelin be used together?
In research, yes. CJC-1295 acts at the GHRH receptor and ipamorelin at GHS-R1a, two separate inputs to the same somatotroph. In normal men, a GH-releasing peptide plus GHRH released more GH than the sum of each alone (Bowers et al., 1990). We sell both pre-blended as CJC-1295 + Ipamorelin 5+5mg.
What is in a CJC-1295 vial?
5mg of CJC-1295 without DAC as lyophilised (freeze-dried) powder. The certificate for batch UKPL-9425 found 4.98mg of peptide in the vial.
Where can I buy CJC-1295 in the UK?
You can buy CJC-1295 online from UK Peptide Lab. The no-DAC 5mg vial is for sale from UK stock, alongside CJC-1295 DAC and the CJC-1295 + Ipamorelin blend. Orders placed before 3pm (UK time) on a working day are dispatched the same day. UK delivery is free over £69.
Is your CJC-1295 5mg UK independently tested?
Yes. Janoshik Analytical tested batch UKPL-9425 at 98.450% purity by RP-HPLC, against a 98.0% specification. The certificate is published with the product, so you can match it to the batch number on your vial.
What is CJC-1295 peptide used for in research?
Studies of GHRH receptor activation, somatotroph biology and the timing of GH release. Many designs pair it with ipamorelin to drive both GH-releasing receptors at once.
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