Growth Hormone Secretagogues
CJC-1295 DAC
5mg
Albumin-binding GHRH analogue with extended half-life. CJC-1295 with DAC linker.
98.65% purity · Third-party tested · Batch UKPL-740 · View certificate
- Same-day dispatch before 3pm, Mon to Fri
- Add £29.01 more for free UK delivery
- Cold-chain shipping. Always. Dry-cold pack, Royal Mail Tracked 24
- Lost, damaged or wrong? Replaced free if you tell us within 48 hours.
- Research use only. For in-vitro laboratory research. Not for use in humans or animals, or in food, drugs or diagnostics. Not evaluated by the MHRA or FDA. The buyer is responsible for handling and regulatory compliance.
Bulk Pricing
Counted across your basket, any mix of products.
| Vials in basket | Discount | Per vial |
|---|---|---|
| 1 | None | £39.99 |
| 3-4 | 5% | £37.99 |
| 5-9 | 8% | £36.79 |
| 10-50 | 12% | £35.19 |
Bacteriostatic Water 10ml
Required to reconstitute lyophilised peptides.
What is CJC-1295 DAC?
CJC-1295 DAC (CJC-1295 with DAC) is supplied as a 5mg lyophilised powder. Its maleimide linker binds covalently to serum albumin, which is what stretches the half-life from minutes to days.
Full description
It is the tetrasubstituted hGRF(1-29) backbone extended by a thirtieth lysine, whose side-chain amine carries 3-maleimidopropionic acid. In modification nomenclature it is Nε30-maleimidopropionyl-[D-Ala2, Gln8, Ala15, Leu27]-Sermorelin-Lys30. DAC stands for Drug Affinity Complex. The maleimide reacts with Cys34 of serum albumin, the most abundant free thiol in plasma, and forms a covalent thioether conjugate. Teichman et al. (J Clin Endocrinol Metab, 2006) estimated its half-life in healthy adults at 5.8 to 8.1 days. It binds the GHRH receptor on pituitary somatotrophs.
CJC-1295 DAC Research Applications
- Albumin bioconjugation: in rats, CJC-1295 gave a 4-fold larger GH area under the curve than hGRF(1-29) over 2 hours. It stayed in plasma beyond 72 hours (Jetté et al., 2005).
- Human pharmacology: after a single dose in healthy adults, mean plasma GH rose 2- to 10-fold for 6 days or more. IGF-I rose 1.5- to 3-fold for 9 to 11 days (Teichman et al., 2006).
- Pulsatility: GH pulse frequency and magnitude were unchanged, while trough GH rose 7.5-fold (Ionescu and Frohman, 2006).
- Knockout models: in GHRH knockout mice, daily CJC-1295 maintained normal body weight and length, and somatotroph proliferation was seen (Alba et al., 2006).
Study details
CJC-1295 DAC is studied in endocrine research on GHRH receptor pharmacology, somatotroph biology and sustained versus intermittent receptor stimulation. Albumin conjugation turns a minutes-long agonist into a multi-day one without changing how it binds the receptor.
CJC-1295 DAC vs CJC-1295 No DAC (Modified GRF 1-29)
The two share the same receptor and the same first 29 residues. Everything that separates them sits at the C-terminus. CJC-1295 without DAC, sold as modified GRF (1-29), stops at residue 29: C₁₅₂H₂₅₂N₄₄O₄₂, 3367.9 g/mol, with a half-life of the order of 30 minutes. CJC-1295 with DAC adds Lys30 carrying 3-maleimidopropionic acid, taking the mass to 3647.2 g/mol. The 279.3 difference is one lysine plus one maleimidopropionyl group, which makes mass the simplest check that a vial holds the DAC form.
Choose the no-DAC form when you need short, controllable exposure. Choose the DAC form when sustained receptor occupancy is the variable under study.
Research Overview
The four backbone substitutions each remove a weak point of native GRF(1-29). D-Ala2 blocks dipeptidyl peptidase-4 cleavage at the Tyr1-Ala2 bond. Gln8 removes an asparagine deamidation site, Leu27 removes a methionine oxidation site, and Ala15 is associated with higher potency.
Jetté et al. (Endocrinology, 2005) made three maleimido hGRF(1-29) derivatives and conjugated them to human serum albumin ex vivo. All three conjugates resisted dipeptidyl peptidase-IV and stayed bioactive in cultured rat pituitary cells. In rat plasma, a CJC-1295 species appeared on the albumin band after 15 minutes and remained beyond 24 hours. Teichman et al. (J Clin Endocrinol Metab, 2006) ran two randomised, placebo-controlled, double-blind trials in healthy adults aged 21 to 61, lasting 28 and 49 days. After repeated doses, mean IGF-I stayed above baseline for up to 28 days.
Product Specifications
- Molecular Formula
- C₁₆₅H₂₆₉N₄₇O₄₆
- Molecular Weight
- 3647.2 g/mol
- CAS Number
- 863288-34-0
- Sequence
- H-Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-Lys(Nε-maleimidopropionyl)-NH₂
- Modification Nomenclature
- Nε30-maleimidopropionyl-[D-Ala2, Gln8, Ala15, Leu27]-Sermorelin-Lys30
- DAC Chemistry
- 3-maleimidopropionic acid, forms a covalent thioether with Cys34 of serum albumin
- No-DAC Counterpart
- Modified GRF (1-29), C₁₅₂H₂₅₂N₄₄O₄₂, 3367.9 g/mol
- Purity
- 98.65% by HPLC
- Batch
- UKPL-740
- Storage
- -20°C lyophilised, 2-8°C reconstituted
- Appearance
- White to off-white lyophilised powder
- Form
- Lyophilised powder
Certificate of Analysis
Third-party tested
- Batch
- UKPL-740
- Purity
- 98.65%
- Specification
- ≥98.0%
- Method
- HPLC-UV/MS
- Tested
- Nov 2025
Need the certificate for an earlier batch? Request an older CoA
Storage and Reconstitution
Store the sealed 5mg vial at -20°C, dry and away from light. Keep reconstituted solution refrigerated at 2-8°C and freeze single-use aliquots for longer holding. Avoid repeated freeze-thaw cycles and prolonged storage of dilute solution at raised pH. Alkaline conditions hydrolyse the maleimide to an unreactive maleamic acid, which destroys the albumin-binding chemistry while the peptide backbone still looks intact by HPLC.
Vials are sold on their own, without bacteriostatic water for mixing or other supplies.
How to reconstitute and handle
Let the vial reach room temperature. Run bacteriostatic water slowly down the inside wall of the vial and swirl gently until clear and colourless. Do not shake or vortex. Keep free thiols out of the preparation: dithiothreitol, beta-mercaptoethanol, free cysteine and reduced glutathione all react with the maleimide. Label the vial with the reconstitution date and refrigerate it.
- Thiol-containing buffer additives quench the DAC function even though the peptide still looks intact by HPLC.
- Swab both vial stoppers with 70% isopropyl alcohol before each needle entry and use a fresh sterile syringe for each transfer.
For the full method, see the peptide reconstitution guide and the reconstitution calculator.
Research References
- hGRF(1-29)-albumin bioconjugates activate the GRF receptor, identification of CJC-1295 as a long-lasting GRF analog (Jetté et al., Endocrinology, 2005)
- Prolonged stimulation of GH and IGF-I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults (Teichman et al., J Clin Endocrinol Metab, 2006)
- Pulsatile secretion of growth hormone persists during continuous stimulation by CJC-1295 (Ionescu and Frohman, J Clin Endocrinol Metab, 2006)
- Once-daily CJC-1295 normalizes growth in the GHRH knockout mouse (Alba et al., Am J Physiol Endocrinol Metab, 2006)
Published research on CJC-1295 DAC is indexed on PubMed. See our full UK buyer's guide for CJC-1295.
CJC-1295 DAC Price (UK)
CJC-1295 DAC 5mg is for sale at £39.99 per vial, supplied from stock in the UK with a published third-party HPLC certificate. UK delivery is £4.50 by Royal Mail Tracked 24, free over £69.
| Vial | Price | Cost per mg | Availability |
|---|---|---|---|
| CJC-1295 DAC 5mgThis page | £39.99 | £8.00 | In stock |
Prices are in GBP per vial and match the basket. See the FAQ for delivery and payment options, and quality & testing for how each batch is checked.
Frequently Asked Questions
What is the difference between CJC-1295 with DAC and CJC-1295 without DAC?
One residue and one linker. CJC-1295 without DAC, or modified GRF (1-29), has 29 residues and weighs 3367.9 g/mol. CJC-1295 with DAC adds Lys30 carrying 3-maleimidopropionic acid, for 3647.2 g/mol. That maleimide binds albumin and gives a half-life of 5.8 to 8.1 days in healthy adults. The receptor and binding site are the same, and only the residence time differs.
What does DAC stand for and how does the albumin binding actually work?
DAC stands for Drug Affinity Complex. Chemically it is a maleimide, which reacts with free sulfhydryl groups. The most abundant free thiol in plasma is Cys34 of human serum albumin, so the peptide forms a stable covalent thioether bond to albumin. Jetté et al. (Endocrinology, 2005) showed this bioconjugation and picked CJC-1295 from three maleimido GRF derivatives.
How long is the CJC 1295 DAC half-life?
Teichman et al. (J Clin Endocrinol Metab, 2006) estimated the half-life at 5.8 to 8.1 days in healthy adults. Unmodified GRF(1-29) lasts minutes. The extension comes from albumin conjugation, which keeps the peptide in circulation as a long-lived depot. In rats, Jetté et al. (2005) found CJC-1295 still present in plasma beyond 72 hours.
Does CJC-1295 DAC flatten the GH pulse?
No, according to the one study that tested it. Ionescu and Frohman (J Clin Endocrinol Metab, 2006) sampled GH every 20 minutes overnight in healthy men before and 1 week after CJC-1295. Pulse frequency and magnitude were unchanged, while trough GH rose 7.5-fold. The idea that the DAC form gives a flat, non-pulsatile profile is not supported by that data.
Is CJC-1295 DAC studied together with Ipamorelin?
Yes. GHRH analogues and growth hormone secretagogues are often studied together because they act at different receptors. CJC-1295 DAC binds the GHRH receptor, while Ipamorelin is a selective agonist at GHS-R1a, the ghrelin receptor. The DAC form stays in circulation for days, so the two compounds have very different time courses, which affects how combined data are read.
Where can I buy CJC-1295 DAC in the UK?
UK Peptide Lab has CJC-1295 DAC 5mg for sale online, batch UKPL-740, dispatched from the UK with a published third-party certificate. Orders placed before 3pm on a working day are dispatched the same day, with free UK delivery over £69. The no-DAC modified GRF (1-29) form is listed separately.
How do I tell cjc dac from the no-DAC form on a certificate of analysis?
Check the mass. CJC-1295 DAC is 3647.2 g/mol and the no-DAC modified GRF (1-29) is 3367.9 g/mol. A mass spectrometry result near 3368 on a vial sold as DAC means it holds the short-acting peptide. Our batch UKPL-740 showed [M+H]+ at 3648.2 m/z, matching the DAC form, with 98.65% purity by HPLC.
What is cjc 1295 dac used for in research?
CJC-1295 DAC is used in preclinical endocrine research on GHRH receptor activation, somatotroph pharmacology and sustained versus pulsatile receptor stimulation. It is also a working example of albumin bioconjugation chemistry for extending peptide half-life.
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