Growth Hormone Secretagogues
Tesamorelin
5mg
Modified GHRH analogue. 44 amino acid sequence with N-terminal hexenoyl modification.
98.21% purity · Third-party tested · Batch UKPL-314 · View certificate
- Same-day dispatch before 3pm, Mon to Fri
- Add £36.01 more for free UK delivery
- Cold-chain shipping. Always. Dry-cold pack, Royal Mail Tracked 24
- Lost, damaged or wrong? Replaced free if you tell us within 48 hours.
- Research use only. For in-vitro laboratory research. Not for use in humans or animals, or in food, drugs or diagnostics. Not evaluated by the MHRA or FDA. The buyer is responsible for handling and regulatory compliance.
Bulk Pricing
Counted across your basket, any mix of products.
| Vials in basket | Discount | Per vial |
|---|---|---|
| 1 | None | £32.99 |
| 3-4 | 5% | £31.34 |
| 5-9 | 8% | £30.35 |
| 10-50 | 12% | £29.03 |
Bacteriostatic Water 10ml
Required to reconstitute lyophilised peptides.
What is Tesamorelin?
UK Peptide Lab supplies tesamorelin peptide, developed under the code TH9507, as a lyophilised powder in 5mg and 10mg vials. Each batch has its own third-party certificate.
Full description
Tesamorelin is an agonist at the GHRH receptor on anterior pituitary somatotrophs. Native GHRH is cleaved between Tyr1 and Ala2 by dipeptidyl peptidase-4 and inactivated within minutes. The hexenoyl cap on Tyr1 blocks that cleavage. Ferdinandi et al. (Basic Clin Pharmacol Toxicol, 2007) reported resistance to DPP-IV, slower degradation in rat, dog and human plasma, and enhanced potency and duration of action.
Tesamorelin Research Applications
Tesamorelin is used in endocrine research on GHRH receptor pharmacology, somatotroph biology and DPP-4 resistance as a peptide stabilisation strategy. Because it acts upstream of the pituitary, endogenous GH secretion and feedback stay in the loop. In a 2 week study of 13 healthy men, Stanley et al. (J Clin Endocrinol Metab, 2011) reported higher mean overnight GH, GH peak area and basal GH secretion. Insulin-stimulated glucose uptake did not change significantly. Clinical trials ran mainly in HIV-associated abdominal fat accumulation, in supervised patient populations.
Tesamorelin vs CJC-1295 vs Sermorelin
All three act at the GHRH receptor. They differ in sequence length and in how they resist enzymatic breakdown. Sermorelin is the truncated GHRH(1-29) fragment with no stabilising modification, so it is the shortest-acting of the three. CJC-1295 is a modified GRF(1-29) analogue, sold with or without the DAC linker that extends its duration. Tesamorelin keeps the full 44 residue GHRH sequence and gets its stability from one hexenoyl group on Tyr1. Choose tesamorelin when a design calls for full-length GHRH with DPP-4 resistance.
Research Overview
Tesamorelin (TH9507) is hGRF(1-44)NH₂ with a trans-3-hexenoyl group on Tyr1 and the native C-terminal amide. In the non-clinical evaluation by Ferdinandi et al. (Basic and Clinical Pharmacology and Toxicology, 2007), plasma GH and IGF-1 rose markedly in pigs, rats and dogs. The apparent elimination half-life in dogs was 21 to 45 minutes. With longer exposure, dogs showed reversible liver and kidney findings and anaemia, which the authors attributed to sustained supraphysiological GH and IGF-1.
Falutz et al. (New England Journal of Medicine, 2007) ran a 26 week randomised, placebo-controlled trial in 412 patients with HIV and abdominal fat accumulation. The primary endpoint was visceral adipose tissue on CT, with IGF-I as a secondary endpoint. The FDA approved tesamorelin as Egrifta in November 2010 for that one indication.
Product Specifications
- Molecular Formula
- C₂₂₁H₃₆₆N₇₂O₆₇S
- Molecular Weight
- 5135.8 g/mol
- CAS Number
- 218949-48-5
- Sequence
- trans-3-hexenoyl-YADAIFTNSYRKVLGQLSARKLLQDIMSRQQGESNQERGARARL-NH₂
- Modification
- trans-3-hexenoyl group on Tyr1, C-terminal amide, 44 residues
- Development Code
- TH9507
- Cysteine Content
- None, the single sulfur atom is the methionine at position 27, so there are no disulfide bonds
- Purity
- 98.21% by HPLC
- Batch
- UKPL-314
- Storage
- -20°C lyophilised, 2-8°C reconstituted
- Appearance
- White to off-white lyophilised powder
- Form
- Lyophilised powder
Certificate of Analysis
Third-party tested
- Batch
- UKPL-314
- Purity
- 98.21%
- Specification
- ≥98.0%
- Method
- HPLC-UV/MS
- Tested
- Nov 2025
Need the certificate for an earlier batch? Request an older CoA
Storage and Reconstitution
When storing tesamorelin powder, keep the sealed vial at -20°C, dry and dark. Heat, light and moisture shorten its shelf life. Once mixed, keep the solution refrigerated at 2-8°C and freeze single-use aliquots for longer holding. Methionine 27 and the two tyrosines are the oxidation-sensitive positions, so minimise headspace air. Avoid strongly alkaline buffers and heat, which could hydrolyse the hexenoyl group that gives DPP-4 resistance.
Vials are sold on their own, without bacteriostatic water for mixing or other supplies.
How to reconstitute and handle
Let the vial reach room temperature so condensation does not settle on the cake. Run bacteriostatic water slowly down the inside wall of the vial and swirl gently until the solution is clear and colourless. Do not shake or vortex, because the long chain and the hydrophobic hexenoyl cap raise aggregation risk. Label the vial with the reconstitution date.
- Swab the stopper of both vials with alcohol before each needle entry and work aseptically.
- Do not leave dilute solutions standing at room temperature.
For the full method, see the peptide reconstitution guide and the reconstitution calculator.
Research References
- Non-clinical pharmacology and safety evaluation of TH9507, a human growth hormone-releasing factor analogue (Basic Clin Pharmacol Toxicol, 2007)
- Effects of a growth hormone-releasing hormone analog on endogenous GH pulsatility and insulin sensitivity in healthy men (J Clin Endocrinol Metab, 2011)
- Metabolic effects of a growth hormone-releasing factor in patients with HIV (N Engl J Med, 2007)
Published research on Tesamorelin is indexed on PubMed. See our full UK buyer's guide for Tesamorelin.
Tesamorelin Price (UK)
Tesamorelin is for sale in 2 vial sizes, priced from £32.99 for 5mg to £49.99 for 10mg. Every size ships from our UK facility, each with its own batch certificate. UK delivery is £4.50 by Royal Mail Tracked 24, free over £69.
| Vial | Price | Cost per mg | Availability |
|---|---|---|---|
| Tesamorelin 5mgThis page | £32.99 | £6.60 | In stock |
| Tesamorelin 10mg | £49.99 | £5.00Best value | In stock |
Prices are in GBP per vial and match the basket. See the FAQ for delivery and payment options, and quality & testing for how each batch is checked.
Frequently Asked Questions
How does tesamorelin work?
Tesamorelin binds the GHRH receptor on anterior pituitary somatotrophs, the receptor used by native GHRH. Its hexenoyl cap on Tyr1 blocks the dipeptidyl peptidase-4 cleavage that inactivates native GHRH within minutes. Ferdinandi et al. (2007) reported DPP-IV resistance and enhanced duration of action. The readout is the pituitary's own growth hormone secretion.
Is tesamorelin legal in the UK?
Tesamorelin is not a licensed medicine in the UK and has never held a UK marketing authorisation. The EU application for Egrifta was withdrawn by the applicant in June 2012. UK Peptide Lab supplies tesamorelin only as a reference material for in-vitro research, not for human or veterinary use. Buyers must be 18 or over and confirm research-only use. This is background, not legal advice.
Is tesamorelin the same as Egrifta?
It is the same molecule but a different article. Egrifta is the US brand of tesamorelin as a prescription medicine, made and labelled under a marketing authorisation. What is sold here is tesamorelin as a research reagent, batch UKPL-314, with its certificate of analysis published in the certificate section. It is not Egrifta and not a medicine.
What is the difference between tesamorelin, CJC-1295 and sermorelin?
All three are GHRH receptor agonists. They differ in how much of the native sequence they keep and how they resist breakdown. Sermorelin is GHRH(1-29) with no stabilising change. CJC-1295 is a modified GRF(1-29), with or without the DAC linker. Tesamorelin keeps all 44 residues and resists DPP-4 through one hexenoyl group on Tyr1.
What is the half-life of tesamorelin?
The FDA prescribing information for Egrifta gives a mean elimination half-life of 26 minutes in healthy subjects and 38 minutes in patients with HIV. In dogs, Ferdinandi et al. (2007) reported 21 to 45 minutes. That is short, but far longer than native GHRH, which DPP-4 degrades within minutes. The GH response outlasts the analogue because the readout is pituitary secretion.
What has published tesamorelin research examined?
The human literature falls into two groups. Stanley et al. (J Clin Endocrinol Metab, 2011) reported higher basal and pulsatile GH secretion in 13 healthy men. Falutz et al. (New England Journal of Medicine, 2007) studied visceral adipose tissue and IGF-I in 412 patients with HIV over 26 weeks. Those findings belong to supervised patient populations and are not claims about this product.
What is in a tesamorelin 5mg vial and how do I mix it?
Each vial contains tesamorelin (CAS 218949-48-5) as a white lyophilised powder, batch UKPL-314. To reconstitute, run bacteriostatic water slowly down the inside wall of the vial. Swirl gently until the solution is clear and colourless, and do not shake or vortex.
Where can I buy tesamorelin in the UK?
UK Peptide Lab has tesamorelin peptide for sale online in 5mg and 10mg vials, dispatched from the UK. Each batch has its own third-party certificate, and the batch on this listing is UKPL-314. Orders placed before 3pm on a working day are dispatched the same day, with free UK delivery over £69.
Is your tesamorelin peptide UK third-party tested?
Yes. Every batch has a third-party certificate of analysis. Batch UKPL-314 was measured at 98.21% purity by HPLC. The certificate is published in the certificate section, so you can check purity and content before ordering.
What is tesamorelin used for in research?
Tesamorelin is used in endocrine research on GHRH receptor activation, somatotroph pharmacology and endogenous growth hormone secretion. It is also a reference compound for DPP-4 resistance as a peptide stabilisation strategy. It is supplied for laboratory research only.
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